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Thelio Mega is the world's smallest quad-GPU workstation for deep learning and scientific computing. We've engineered the chassis to ensure your top-line components perform to their fullest potential.

  • Quad-GPU Compute Workstation
  • Multi-Core Threadripper 3 CPUs
  • Up to 256 GB of ECC Memory
  • PCIe 4.0 NVMe Storage
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Side view of the machine with etchings, 3-Body Problem intake vent, and wood veneer.
  • Quad-GPU Compute Workstation
  • Multi-Core Threadripper 3 CPUs
  • Up to 256 GB of ECC Memory
  • PCIe 4.0 NVMe Storage
Detail of the machine exterior showing the 3-Body Problem intake vent.


Thelio Mega’s thermals are actually two separate systems, as we found it more effective to divide and conquer. Unique airflows keep heat generated by the CPU and GPU from mixing, exhaust air effectively, and prevent throttling.


Full-Core GPU Compute

Heat builds up quickly when you have up to 4 NVIDIA Quadro RTX GPUs stacked atop one another. Rather than use a single vent to cool the entire system, intake fans on the bottom and side panels blow cool air directly onto your GPUs. Everything down to the GPU brace has been tested for maximum thermal efficiency. The result is consistent access to every last core of performance in your system.

Open Bench CPU Performance

Meanwhile, a separate duct isolates the airflow to your CPU. A dedicated intake vent on the side panel directs cool air towards the heat sink. In what’s called a closed-loop phase change, actuating fluid evaporates into a gas, drawing thermal energy away from the CPU and towards the heat sink. Here, it is cooled into a liquid and returned to the transfer plate. The hot air then exits via the exhaust port. The process yields performance similar to if your components were sitting on a test bench.

Quiet, Adaptive Cooling

We tested a wide variety of fan sizes and alignments until we arrived at the most effective solution. Large 140mm fans move air more effectively at a lower RPM, producing quieter acoustics. The Thelio IO board allows your operating system to monitor the temperature of your GPUs and adjust fan speeds for intensive computing.


Seconds add up quickly when working with large datasets. Thelio Mega is equipped with high-performance components to save you time on reaching your next discovery.


Up to 4 NVIDIA Quadro GPUs

Quadro GPUs use ECC memory to reliably process tasks at rapid speeds. NVIDIA-exclusive CUDA and Tensorflow tools thrive at high core counts, needing only a single line of code to install on Pop!_OS.

Up to 128 CPU Threads

Multitasking is key. AMD Ryzen Threadripper processors provide the greatest performance for workstations while supporting your graphics cards with up to 128 CPU threads.

Long-Term Storage

Up to 32TB M.2 NVMe storage. Up to 64TB additional storage on hot swappable 2.5" drives. Cooled aluminum drive cages keep your drives performant, while rubber stoppers mute noisy vibrations. Expandable storage lets your system grow with you from project to groundbreaking project.

Cloud-Friendly Network Connection

Transfer data between devices at breakneck speeds. Dual 10GB Ethernet Ports operate at speeds 10 times faster than a standard Ethernet connection.


Thelio desktops are designed to provide easy access to your motherboard for upgrades and repairs. Slip in drives, add memory, and upgrade graphics cards at will with our open hardware design.


Side Panel Access

Unplug your ducts and access everything in the system. No obstructive wires, no loose parts.

Pre-Wired for Upgrades

Any wires you’ll ever need are already provided inside the system. To level up your graphics power, simply plug in your new GPU and fire up those CUDA Cores.

Never Lose Screws Again

The screw bay on the GPU cooling panel houses enough screws to install the maximum number of 2.5” storage SSDs. They will be with you, always.


Rigid aluminum is cut, powder coated, and molded into a light, durable chassis. From the 3-Body Problem intake to the subtle mountainscape, Thelio Mega adds elegance and character to your workplace. Personalize it with natural or stained wood veneer options.

Detail of the machine exterior showing the 3-Body Problem intake vent.
Detail of the machine interior showing storage drives inside the aluminum cages.
Detail of the machine exterior showing geometric etching of mountains.
Detail of the aluminum chassis without any components installed.
Detail of the exterior showing combination of wood veneer and powder-coated aluminum.
Detail of the interior showing System76 logo punched on the metal screw cover.
Detail of the exterior showing artful intake vent with holes shaped as rockets.
Detail of the interior showing large CPU cooling duct.

Add Ports with Launch Keyboard

  • Match your Thelio
  • Dual, high-speed USB-A and USB-C ports
  • Optimized for Pop!_OS
  • Fully configurable
  • Customizable colors and LEDs
  • Buy separately or add when configuring your Thelio


What could you accomplish at peak efficiency? Train AI to predict viral mutations. Map the world’s oceans and their currents. Simulate the evolutionary phases of a star.

Thelio Mega pairs with Pop!_OS to keep you progressing at full speed, every step of the way. Auto-Tiling, Workspaces, and Keyboard Navigation accelerate your workflow with comprehensive shortcuts.

Brain scans, showing glucose levels, that help researchers diagnose degenerative diseases with artificial intelligence.
Side view of the machine showing walnut veneer component.

Thelio Mega


Tech Specs

Operating System

Pop!_OS 21.04 (64-bit), Pop!_OS 20.04 LTS (64-bit), or Ubuntu 20.04 LTS (64-bit)


AMD® 3rd Gen Ryzen™ Threadripper™ series


Up to 4 x NVIDIA® Graphics

Video Ports

Dependent on GPU selection:

GeForce RTX 3090: 2 × DisplayPort, 2 × HDMI

Quadro RTX 4000: 3 × DisplayPort, 1 × DisplayPort over USB-C (VirtualLink)

Quadro RTX 5000: 4 × DisplayPort, 1 × DisplayPort over USB-C (VirtualLink)

Quadro RTX 6000: 4 x DisplayPort, 1 × DisplayPort over USB-C (VirtualLink)

Quadro RTX 8000: 4 x DisplayPort, 1 × DisplayPort over USB-C (VirtualLink)


Up to 256 GB Quad Channel ECC DDR4 @ 3200 MHz


Up to 88 TB, 4 × M.2 PCIe Gen4 NVMe and 2.5″ SATA drives

Rear Ports

7 x USB 3.2 Gen 2 Type-A, 1 x USB 3.2 Gen 2 Type-C, 2 x RJ-45 LAN

Rear Audio

5 × Audio Jacks, 1 × Optical S/PDIF out


Intel® 10GbE LAN chip (10 Gbit/5 Gbit/2.5 Gbit/1 Gbit/100 Mbit), supporting 2 RJ-45 ports

Built-in Intel® Wireless-AC (a/b/g/n/ac/ax) with Bluetooth 5.0

Power Supply

1600W 80+ Certified (90% or greater power efficiency)


Height × Width × Depth

18.82″ × 10.35″ × 17.24″ (478 × 263 × 438mm)